The Aging Puzzle: How NAD+ Levels Decline Over Time
Mitochondria, the powerhouses of the cell, rely on NAD+ to produce ATP, the body’s primary energy currency. When NAD+ levels drop, mitochondrial enzymes like those in the Krebs cycle and electron transport chain become less effective. This results in reduced energy production, leaving cells unable to perform their basic functions. The effects are particularly evident in energy-hungry tissues like muscles, which become weaker, and the brain, where cognitive decline ensues.
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