D-Tox with NAC & Milk Thistle – Healthy Liver Support | 60 Vegetarian Capsules

D-Tox is a liver support supplement with 200 mg each of N-acetyl cysteine (NAC), burdock root, dandelion root, Oregon grape root and milk thistle seed extract standardized to 80% silymarin, plus 50 mg of DIM and 5 mg of D-limonene in every 2-capsule serving. Each bottle holds 60 vegetarian capsules. D-Tox supports healthy liver function.†

Your liver works around the clock, processing nutrients, hormones and the everyday compounds that come in with food, drink and air, and getting them ready to leave the body. D-Tox is for adults who want to back up that normal work with NAC, milk thistle and three roots with a long history in traditional herbal practice.†

You don't have to wait until your 50s to think about this. If you're in your 30s or 40s and already minding what you eat, how you sleep and how you move, D-Tox is an easy add. Small, steady habits now are how you add life to your years later. One honest note: D-Tox doesn't "flush" anything. It supports what your liver already does.†

Why people take D-Tox

• Supports healthy liver function.†
• Provides 200 mg of NAC per serving, a source of cysteine your body uses to make glutathione.†
• Supports the body's normal antioxidant defenses, with NAC as raw material for glutathione.†
• Brings together milk thistle, dandelion root, burdock root and Oregon grape root, four botanicals with a long history of traditional use for the liver.†
• Adds 50 mg of DIM, a compound that also forms when you eat broccoli and cabbage, studied for its role in how the body processes estrogen.†

What's in each serving

Serving size: 2 Vegetarian Capsules. Servings per container: 30 (60 capsules per bottle). Other ingredients: Vegetable cellulose (preservative-free, from capsule shell), magnesium trisilicate, magnesium stearate, cellulose, and silica. The label states: "NO corn, soy, yeast, gluten, milk & egg products, sugar, starch, or preservatives."

How D-Tox works

N-acetyl cysteine (NAC): 200 mg

Start with glutathione, the most abundant small sulfur-containing antioxidant your cells make. Its two main jobs: it neutralizes oxidants, and it latches onto reactive compounds so the body can move them out (an overview of glutathione's protective roles).† Your body builds glutathione from three amino acids (glutamate, cysteine and glycine), and NAC is a way to make more cysteine available for the job.

NAC is cysteine with an acetyl group attached. Its main antioxidant role comes from helping cells raise their own glutathione, and its safety record is well established (a review of NAC and human health).†

In a 30-day double-blind crossover trial in 36 young men sorted by their starting glutathione, NAC brought glutathione back up and lowered oxidative stress markers only in the low-glutathione group. In men who started moderate or high, it didn't change their antioxidant status. Limits: the dose was at least 1,200 mg of NAC a day, far more than a serving of D-Tox, and everyone was a young man. The takeaway we'd stand behind: NAC supports glutathione, and more doesn't help if you're already well supplied.†

Milk thistle seed extract: 200 mg, standardized to 80% silymarin

Milk thistle is a spiny, purple-flowered plant whose seeds have been used for the liver for centuries. The compounds that matter are called silymarin, a mix of flavonolignans such as silybin, silychristin and silydianin. "Standardized to 80% silymarin" means the extract is held to a set silymarin content, so each serving carries about 160 mg of silymarin. Plants vary; standardizing keeps the amount steady, and potency is one of the four tests every incoming ingredient lot gets.

Silymarin is absorbed and processed fast. In a small study in 3 healthy volunteers given a single 600 mg dose of standardized extract, it showed up in the blood mostly as conjugates (water-soluble forms the body tags for removal), with half-lives of about 1 to 3 hours for the free forms and 3 to 8 hours for the conjugated forms. Three people is tiny, so read it as a sketch, but it's one reason splitting your capsules across two meals, as the label directs, makes sense.

Silymarin also has a long safety record. An updated review of silymarin safety found it well tolerated in human studies, even at 700 mg three times a day for 24 weeks, with occasional stomach upset such as nausea or loose stools.

Dandelion root and burdock root: 200 mg each

Both are roots you may have pulled out of a garden, and burdock is also a vegetable, sold as gobo in Japanese grocery stores. Both are rich in inulin, a type of fiber, and herbalists have used both for the liver and digestion for generations. The straight version: human research on either root is thin and mostly lab and animal work. They're here for their traditional role alongside milk thistle, and we don't hang a separate promise on them.

Oregon grape root: 200 mg

Oregon grape (Mahonia aquifolium) is a holly-leaved shrub native to the Pacific Northwest, and it's Oregon's state flower, so this one is close to home. Its bright yellow root gets its color from berberine and related alkaloids, and it has a long history as a traditional bitter. Human research on taking the root by mouth is limited, so it's a traditional companion here, not a headline. Berberine is also why anyone on medication should check with a practitioner first.

DIM: 50 mg

Diindolylmethane (DIM) forms in your stomach when indole-3-carbinol, from broccoli, cabbage, kale and Brussels sprouts, meets stomach acid. It's studied for its role in how the body processes estrogen. Most human DIM research is small and done in specific groups, so we don't make a hormone promise for it.

D-limonene: 5 mg

D-limonene is the compound that makes orange peel smell like orange peel. There's 5 mg here, and we make no claims for it. It's on the label, so it's on this page.

How to take D-Tox

The label's directions: "One to two capsules twice daily, immediately before or during a meal, as a dietary supplement."

In practice, that means taking it with two of your meals, such as breakfast and dinner. If you also take other products with milk thistle or NAC, add up the totals and run them by your practitioner.

The label warns: "WARNING: Not recommended while pregnant or lactating unless directed by health care practitioner." It also carries this California Proposition 65 warning: "WARNING: This product can expose you to chemicals including Lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov."

Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition.

Don't take our word for it

• 52 years and counting. We've been making supplements in Oregon since 1974, and we're not getting old either.
• Verified by independent labs. ISO 17025-accredited labs check our test results.
• Every ingredient lot tested before use. Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot for identity, potency, heavy metals and microbes.
• If it misses spec, it doesn't go in a bottle. More than 99% of our tests pass, and the lots that don't are turned away.
• A certificate of analysis for every lot. See the certificates of analysis for this product, listed by lot number.

Made in the USA. Made and tested in Mt. Angel, Oregon. Mt. Angel is a farm town of about 3,500 people in the Willamette Valley. Our UL-certified cGMP facility there keeps the formulators, the makers and the testers under one roof. The company has been owner-run since 2017, and the owners work in the building too.

Frequently asked questions

How many D-Tox capsules should I take a day?

Follow the label: one to two capsules twice daily, immediately before or during a meal. The Supplement Facts panel lists one serving as 2 capsules, and each 2-capsule serving gives you 200 mg of NAC and 200 mg of milk thistle seed extract.

Does D-Tox flush toxins or cleanse my liver?

No. D-Tox doesn't flush anything out of you. Your liver processes what comes in around the clock on its own, and D-Tox supplies NAC and botanicals that support that normal work.†

How long until I notice a difference?

You may not notice anything, and that's expected: supporting normal liver function happens out of sight.† Think of D-Tox as a steady daily habit, not a quick fix.

Can I take D-Tox with Milk Thistle or LIV'R Support?

You can, but you'd be doubling up. Our Milk Thistle and LIV'R Support both contain milk thistle extract too (LIV'R Support also has dandelion root and Oregon grape root), so add up the totals and check with your practitioner before stacking them.

Is D-Tox safe to take with medication?

Ask your healthcare practitioner or pharmacist first. Silymarin has few known drug interactions, but the safety review above advises caution with drugs that have a narrow therapeutic window, and the berberine in Oregon grape root can change how some medications are processed. Bring the bottle along.

Why does the label carry a California Prop 65 warning?

California's Proposition 65 calls for a warning when a product could expose someone to a listed chemical, including lead, above levels the state sets. Our label carries it, so we repeat it word for word above. Every incoming ingredient lot is tested for heavy metals, and every lot of D-Tox has a certificate of analysis.

Keep learning

• Certificates of analysis for our other products
• Milk Thistle, a single-herb liver option
• LIV'R Support, a broader liver formula

References

1. Forman HJ et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2008. PubMed
2. Tenório MCDS et al. N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants (Basel). 2021. PubMed
3. Paschalis V et al. N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione. Free Radic Biol Med. 2017. PubMed
4. Wen Z et al. Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. Drug Metab Dispos. 2007. PubMed
5. Soleimani V et al. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Phytother Res. 2019. PubMed

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.