Triple B-12 Dots 1,000 mcg – Energy & Nervous System Support | 60 Dots

Triple B-12 Dots are a cyanocobalamin-free vitamin B12 supplement. Each small dot provides 1,000 mcg of vitamin B12 (41,666% of the Daily Value) from three forms: 500 mcg hydroxycobalamin, 400 mcg adenosylcobalamin and 100 mcg methylcobalamin. You let one dissolve in your mouth, and each bottle holds 60 dots. Vitamin B12 supports normal energy production and a healthy nervous system.†

People reach for B12 when they think about energy, and there's real biology behind that: your cells can't run two key energy and methylation reactions without it.† It matters most when intake or absorption runs low. B12 occurs naturally only in animal foods, so anyone eating little or no meat, fish, eggs or dairy needs another source. And the NIH advises adults over 50 to get most of their B12 from fortified foods or supplements, because many older adults don't make enough stomach acid to free B12 from food (the NIH's consumer guide to vitamin B12).

If you're in your 30s or 40s and building habits now so you can still hike, lift and keep up at 75, a daily B12 dot is one of the easiest to start. Aging isn't optional. Getting old is.

Why people take Triple B-12 Dots

• Supports normal energy production, as the coenzyme your mitochondria need to turn parts of protein breakdown into fuel for the energy cycle.†
• Supports healthy nervous system function.†
• Supports normal red blood cell formation and DNA synthesis.†
• Supports healthy homocysteine metabolism by helping recycle homocysteine back into methionine, working alongside folate.†
• Helps maintain healthy B12 levels for people who eat few animal foods and for adults over 50.†

What's in each serving

Serving size: 1 Dot. The panel doesn't print a servings-per-container line; the bottle holds 60 dots, which is 60 servings at the one-dot serving size. Other ingredients: Maltodextrin, acacia, cellulose, orange juice, magnesium stearate, and natural cinnamon flavor. The label states: "NO soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives." It also states: "Does not contain cyanocobalamin."

How Triple B-12 Dots work

Vitamin B12 is a coenzyme, not a stimulant

B12 doesn't work like coffee. It's a helper molecule two specific enzymes can't run without. Your body uses two working forms, methylcobalamin and adenosylcobalamin, and converts other forms (like hydroxycobalamin) into those two (NIH fact sheet on vitamin B12). Triple B-12 Dots give you both working forms ready-made, plus hydroxycobalamin, with no cyanocobalamin.

Adenosylcobalamin (400 mcg): the mitochondrial form

Adenosylcobalamin (dibencozide is another name for it) works inside your mitochondria, the parts of your cells that make most of your energy. There it helps an enzyme called methylmalonyl-CoA mutase convert leftovers from breaking down certain amino acids into a compound that feeds straight into the energy cycle (Froese et al., 2019). In plain terms, it keeps part of your protein metabolism flowing into fuel.†

Methylcobalamin (100 mcg): the methylation form

Methylcobalamin works in the main body of the cell with an enzyme called methionine synthase. That enzyme recycles homocysteine into methionine, which your body then uses to make SAMe, its most important methyl donor. The same step takes a methyl group from folate, which keeps folate moving through the cycle your cells use to build DNA (Froese et al., 2019). That's why B12 and folate are usually talked about as a team.† A review of B vitamins and the brain lists these same jobs (energy production, DNA synthesis and methylation) among the ways B vitamins support normal brain function (Kennedy, 2016).†

Hydroxycobalamin (500 mcg): the form your cells convert

Hydroxycobalamin (often spelled hydroxocobalamin) makes up half of the B12 in each dot: 500 of the 1,000 mcg. Your cells convert it into either working form, so it can feed both the mitochondrial job and the methylation job (NIH fact sheet on vitamin B12).†

Why 1,000 mcg when the Daily Value is 2.4 mcg

Because you absorb only a small share of a large dose. Your gut's main B12 absorption system fills up at about 1 to 2 mcg at a time, and the NIH puts absorption at about 1.3% of a 1,000 mcg dose: roughly 13 mcg per dot, still more than five times the 2.4 mcg Daily Value (NIH fact sheet on vitamin B12). A systematic review of absorption studies found the same pattern with food: absorption ranged from 83% of a 3 mcg dose (from mutton) down to 4.5% of a 38 mcg dose (from liver) (Doets et al., 2013).

What the research does and doesn't show

It shows that intake matters. In 299 healthy adults aged 18 to 50, blood markers of B12 status leveled off once dietary intake reached about 4 to 7 mcg a day, above the 2.4 mcg Daily Value (Bor et al., 2010). In 2,999 adults from the Framingham Offspring Study, 8% of supplement users had blood B12 below 185 pmol/L, compared with 20% of people who didn't take supplements; that's an observational snapshot, not a trial (Tucker et al., 2000).

It doesn't show that B12 supplements sharpen your thinking. A systematic review of 14 randomized trials found no clear effect of B6, B12 or folic acid supplements on cognitive test scores, and the authors rated most of those trials as low quality (Balk et al., 2007). And to be straight with you, none of the studies above tested this three-form blend itself. What we can tell you is exactly what's in each dot and how each form is used.

How to take Triple B-12 Dots

The label directions, word for word: "One or more dots daily, as a dietary supplement. For best absorption allow dot to dissolve in mouth completely."

• Let the dot dissolve fully in your mouth instead of swallowing it whole.
• The label doesn't call for food, so pick whatever time of day you'll remember.
• One dot is the label's serving. Not sure whether you need more? Ask your healthcare practitioner.

Ask your healthcare practitioner before use if you are pregnant, nursing, taking medication, or have a medical condition. Some common medications, including acid-reducing medicines, can lower B12 levels over time.

Don't take our word for it

We've been making supplements in Oregon since 1974. Fifty-two years in, here's how we back up what's on this label:

• Verified by independent labs. ISO 17025-accredited labs check our test results.
• Every ingredient lot tested before use. Federal rules only require an identity test on incoming dietary ingredients. We test every incoming lot, the B12 included, for identity, potency, heavy metals and microbes.
• If it misses spec, it doesn't go in a bottle. More than 99% of our tests pass, and the lots that don't are turned away.
• A certificate of analysis for every lot. Every lot of Triple B-12 Dots gets its own certificate of analysis.

Made in the USA. Made and tested in Mt. Angel, Oregon. Triple B-12 Dots are made in our UL-certified cGMP facility in Mt. Angel, a farm town of about 3,500 in the Willamette Valley. The people who formulate, make and test them work under one roof, and the owners work in the building too. We're not getting old either.

Frequently asked questions

How much vitamin B12 is in each dot?

Each dot has 1,000 mcg of vitamin B12, which is 41,666% of the Daily Value. It comes from 500 mcg hydroxycobalamin, 400 mcg adenosylcobalamin and 100 mcg methylcobalamin.

Is 1,000 mcg of B12 too much?

No upper limit has been set for vitamin B12; the Food and Nutrition Board didn't establish one because of B12's low potential for toxicity. If you take medication or have a medical condition, check with your healthcare practitioner first.

Why are the dots cyanocobalamin-free?

Because we chose the two forms your cells actually work with, plus hydroxycobalamin, which cells convert into both. Your body converts cyanocobalamin into the working forms too, so this is a formulation choice, not a knock on other forms.

How long until I notice anything?

There's no set timeline, and you shouldn't expect a jolt, because B12 isn't a stimulant. It works as a helper in everyday cell reactions, so if your intake was already good you may not feel a difference at all. That's normal.

Can I take it with B-12 Essential Trio or B-Complex?

You can, but both already contain B12, so check the totals first. B-12 Essential Trio liquid with folinate and B6 has 2,000 mcg of methylcobalamin per serving, and our B-Complex with all eight B vitamins has 100 mcg of vitamin B12 per capsule. If you want to combine them, ask your healthcare practitioner.

Are Triple B-12 Dots vegan?

The label doesn't make a vegan claim. It does state "NO soy, salt, yeast, gluten, milk & egg products, sugar, starch, or preservatives," and the other ingredients are listed in full above so you can decide for yourself.

Keep learning

• P5P 50 mg, the coenzyme form of vitamin B6, another B vitamin involved in homocysteine metabolism.†
• Everyday Liquid Sunshine 2 vitamin D3 and K2 drops, if you're building a simple daily foundation.

References

1. Froese DS et al. Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis. 2019. PubMed
2. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016. PubMed
3. Doets EL et al. Systematic review on daily vitamin B12 losses and bioavailability for deriving recommendations on vitamin B12 intake with the factorial approach. Ann Nutr Metab. 2013. PubMed
4. Bor MV et al. Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr. 2010. PubMed
5. Tucker KL et al. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr. 2000. PubMed
6. Balk EM et al. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007. PubMed

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.